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L-Glutamine for IBS – Get Support for IBS Relief

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Support Your Health. Improve Leaky Gut Issues with L-Glutamine.

Great Health Begins in the Gut

Get the Right Support for a Healthy Gut

If you are suffering from a condition like IBS, many things can be done to support your healing journey. One of the simplest and most effective things to do is begin a professional gut health program that includes various supplements and lifestyle upgrades. These serve to shift your situation into a more positive path. Using L-Glutamine for IBS challenges1 is one of the most agreed upon gut supporting protocols around.

Do you know that 80% of your immune system is centralized in your gut?2 This is a relatively recent scientific finding that has been taking the world by storm ever since. Although Hippocrates, the great-grandfather of western medical ideology, once stated ‘all disease begins in the gut’ we still did not have any solid foundation to stand on scientifically. Fortunately for the modern health-seeker, we now have empirical data that supports this claim.


From now on, you’ll safely and confidently walk with the understanding that you can have a direct impact on your overall health and wellbeing. This is all done through careful attention to what’s going on in your gut. What does this look like? First, it takes a personal responsibility to take charge of improving your health.


IBS – An Avoidable Pain in the Gut (Butt?)

All Jokes Aside, Getting Support Can Go A Long Way for IBS Challenges.

Insofar as gastrointestinal conditions are concerned, IBS is one of the most common. Even so, this does not lessen the burden of its often unyielding challenges. If you are suffering from IBS, you know first hand the kinds of conditions (shituations?) that arise. From painful bloating and gas, cramps, and liquid stools, to all-out bathroom battles just to get the day started. If someone gave you a tool that could help get you to the other side of these challenges, would you accept the gift? What if this tool is natural and in perfect alignment with what your body already produces but needs a bit more of? This is exactly what L-Glutamine is for.

L-Glutamine for IBS

The Most Readily Available Free Amino Acid in the Body

The body does a miraculous job of fixing itself when you get the right support, feed it what it needs, get adequate rest, live through the heart, keep good company, and do what you love in the world.3 An absence of any one of these parameters opens the doors to dis-ease in your life.4-6


That’s right. Disease is often an indicator that we are living a life through dis-ease—living out of natural balance. One of the ways to restore this balance in a world so full of topsy-turvy conditions is through healthy natural supplementation.7-9


When it comes to supplements that help IBS, L-Glutamine can really help you to alleviate your issues. From relieving inflammation to boosting your overall athletic performance, every stage of your healing journey is supported.


Inflammation Relief

According to a study published in Clinical Immunology in 199910, L-Glutamine helps to reduce the production of inflammatory cytokines. This is done by normalizing the TH2 immune response that is responsible for these cytokines being produced. What this means for you is reduced inflammation and pain.


More than this, your entire GI tract is improved through daily supplementation with L-Glutamine. This is because L-Glutamine is one of the key nutrients the small intestine needs to build healthy cells, repair itself, and function optimally.11


Leaky Gut Relief (Including Ulcers)

IBS is an inflammatory autoimmune disease. The common culprit causing the condition to begin with is leaky gut. Leaky gut (aka intestinal permeability) is caused by the separation of the tight junctions in the cell wall of the intestines. When this occurs the immune system is compromised and all kinds of autoimmune conditions begin to arise.


With L-Glutamine as the main source of fuel for building and repairing cellular tissue in the small intestine, supplementing with it can significantly increase your rate of relief.10 It has also been scientifically shown in animal studies to have benefits in healing ulcerative colitis and IBS.12


If you have IBS, you very likely have leaky gut and will benefit immensely as you supplement with L-Glutamine. Check out the low FODMAP gut program for more information.


Help Diarrhea and Loose Stools

One of the biggest challenges with IBS is loose stools and diarrhea. This can be a real problem for the body for many reasons. Most importantly, you cannot properly absorb the nutrients of the foods you eat as they pass through the GI tract. This can cause weight loss (or weight gain due to the body storing fats for later use), malnutrition, and sleep deprivation, among other things.


L-Glutamine supplementation helps to balance mucus production in the gut. This helps to make sure that your bowel movements are more comfortable and stable.13


The Gut-Brain Connection – Boost Cognitive Function

Brain fog is a condition that arises all the time in people suffering from GI issues.14 One of the reasons for this is a deficiency in L-Glutamine. For the brain to function properly, the neurotransmitter Glutamate needs to be produced, and Glutamine is required in this process. It’s called the Glutamine-Glutamate cycle,15 and it’s essential for clearing out the brain fog. Balancing this cycle is key and can influence healthy aging,16 clear thinking, and an overall sense of wellbeing.


Natural Weight Loss Support

One of the most prevalent issues in the world today is obesity. It has many causes, but one thing that happens in most cases is a severe deterioration of the health of the gut. When the gut is compromised many bodily functions begin to work less efficiently and can cause even more weight gain, diabetes, and GI diseases.


If you are working on losing weight through a healthy exercise routine, L-Glutamine can help expedite the process through natural weight loss support. This is happening through the nearly 400% increase of HGH (human growth hormone) in the bloodstream from supplementing with L-Glutamine. This massive spike in HGH leads to a spike in metabolic rate as well giving you the ultimate ‘after-burn’ effect post workout. It because of this after-burn effect that you see an increase in fat-burning, lean muscle mass building, and overall weight loss.17


Compromised Tight Junctions – Closing Gaps in The Gut

Sealing-Up Intestinal Permeability (aka Leaky Gut) Once And For All

What is leaky gut anyway? In short, it’s a condition that occurs when the tight junctions in the cellular wall of the intestines are compromised. These tight junctions


Insofar as a defense against bodily harm is concerned, when your gut is healthy, the intestinal lining produces enough mucosa to create a protective barrier that prevents various pathogens, food particles, undigested proteins, and various microbiota from entering the bloodstream. On the offensive side, a healthy mucosal lining allows for the healthy absorption of key nutrients through the gut lumen from the various foods we eat (or supplements we take).


Intestinal permeability describes a pathological situation wherein this mucosal lining is compromised. This causes, among other things, increased uptake of undigested foods, antigens, microbes, intestinally derived endotoxin, inflammatory mediators, pathogenic macromolecules and more. This clearly does not sound like a walk in the park! That’s because it’s not. This is a dangerous situation to be in and is the beginning of the end of systemic health if not looked into and course corrected immediately before something serious arises.


When we say something serious, we’re serious. Nearly every chronic autoimmune disease known to science is birthed under these conditions, including but not limited to diabetes, Crohn's, multiple sclerosis, Alzheimer's, rheumatoid arthritis, allergies, and some forms of cancer.


L-Glutamine Helps Repair Tight Junctions

It’s now widely accepted that L-Glutamine is responsible for helping to repair the gut lining through the proliferation of intestinal cells.18 In a proper gut health program, you will find that there are a few things in common. First, a low FODMAP diet will likely be a start. Alleviating and preventing SIBO (small intestine bacterial overgrowth) formations is a primary aspect of a gut overhaul. SIBO is often the reason for many of the more uncomfortable symptoms arising like bloating, gas, and liquid stools.


In addition to addressing SIBO, supplementation with key nutrients, minerals, amino acids, probiotics, and select natural flora play a significant role in building the gut back up and sealing off those tight junctions once and for all. This is where L-Glutamine plays a considerable role. Because this amino acid is so essential in the process of building and repairing the endothelial tissue, getting additional support through supplementation is visceral (pun intended).


Rather than giving you the raw jargon from the medical literature,19-22 suffice it to say that you are in good hands with L-Glutamine. The medical community has established that you can have faith that in the right dosage, under the right care, on the right program, you can have a very high chance of getting rid of leaky gut once and for all.


L-Glutamine Precautions – Side Effects and Contraindications

Each Healing Journey is Unique. Be Aware of What Your Body Needs.

Like anything in the world of health and wellness, not every human body can be treated the same as any other. There is always something unique about you that is different from others and the same rings true for your gut health program. By carefully listening to your medical professional or wellness consultant, as well as your own body, you can have a safe and successful healing journey you’ll be proud to share with the world.


L-Glutamine does have a small list of precautions that you should be aware of before opting into a full gut program that includes this supplement in its daily protocol. Here are some of the things to be mindful of.


Medical Contraindications

If you are taking certain medications, supplementing with L-Glutamine can pose a health risk. This is called a ‘contraindication’ in medical jargon. Here are the three main contraindications.*



Lactulose is used to help decrease the levels of ammonia in the body. L-Glutamine acts to increase the levels of ammonia. Taking the two together can counteract the efficacy of the Lactulose medication.



Some researchers are suggesting that there may be a decrease in the efficacy of certain cancer medications if used in conjunction with L-Glutamine. These are not conclusive; however, it is wise to mention this just in case.


Seizure Medication (Anticonvulsants)

The efficacy of drugs like phenobarbital, primidone, valproic acid, gabapentin, carbamazepine, phenytoin, or any other anticonvulsant may be negatively impacted by the use of L-Glutamine. These medications affect the brain, and so does L-Glutamine. Taken together, these substances may counteract each other, or worse, cause more problems.


*Remember to always consult your medical professional before taking any supplements, however natural they may be, including L-Glutamine. Depending on the circumstances, you may cause more problems than benefits.


Final Thoughts on Using L-Glutamine for IBS

Support Optimal Gut Health Through a Gut Health Program

It is quite clear that using various strategic supplements at the right time can have a positive effect on healing the gut. L-Glutamine is one of the most important of these supplements. It helps to repair and regrow endothelial cells in the intestine thus creating an environment conducive to receiving the various other vitamins and nutrients used in your gut health protocol. Essentially, when you heal the lining of the gut—and then introduce a healthy lifestyle—your digestion improves, discomfort decreases, bowel movement improves, metabolism balances, hormone production stabilizes and overall wellness begins to dawn over the horizon.


L-Glutamine for IBS

If your gut health professional suggests you begin to use L-Glutamine for IBS, you can walk in confidence that you are receiving, and heeding, great advice. Take your journey day-by-day, listen to your body, and ask for any help you need. With your determined will to win, the support of your gut health program, and your body’s natural ability to heal itself when it gets what it needs and purge what it doesn’t, you will get through your gut health challenges once and for all.  


























AuthorAbout The Author: Drew is the founder of The Gut Program and a gut health expert. His work has been featured on The Gut Program,, Ask Men and The Gut BrainConnection Community. Learn more at his personal site.


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